Lipid ratios linked to benign prostatic hyperplasia risk

FRIDAY 4 Nov. 2022 (HealthDay News) – In the Chinese population, the ratio of triglycerides to high-density lipoprotein (TG/HDL-C) and total cholesterol (TC)/HDL-C ratio are associated with an increased risk of benign prostatic hyperplasia (BPH) , according to a study published online Oct. 3 Limits in nutrition.

Chen Zhu, of The First Affiliated Hospital with Nanjing Medical University in China, and colleagues examined the association between lipid ratios and the risk of BPH in Chinese men who underwent routine checkups from January 2017 to December 2019. A total of 24,962 men were enrolled in the study. .

The researchers found that 18.46 percent of the participants were identified as incidental BPH cases after health screenings over two years. Significant associations with BPH risk were seen for older age, body mass index, prostate-specific antigen, TGs, low-density lipoprotein cholesterol, TG/HDL-C ratio, TC/HDL-C ratio, and lower HDL-C; the association for TC was not significant. In the multivariate model examining quartiles of TG/HDL-C and TC/HDL-C, higher TG/HDL-C and higher TC/HDL-C were associated with an increased risk of BPH (odds ratios, 2.11 and 1.67) . Stratified analyzes showed that the relationship between TG/HDL-C and BPH risk was predominantly positive with increasing age (35 years and older). A higher TG/HDL-C ratio may be a risk factor for BPH in individuals 35 years of age and older with normal TG and HDL-C.

“More attention should be paid to those with higher TG/HDL-C in the health management process, and lifestyle modifications or lipid-lowering drugs to help prevent BPH risk in middle-aged and older adults,” the authors write.

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